Research
組織工程的發展對於應用在修補或治療受損的器官上占有很重要的地位,而組織工程中材料與細胞的交互關係是本實驗室非常重視的一個課題。在耳鼻喉科醫學的應用上,利用組織工程的方法去重現唾液腺結構的生成,以及了解唾液腺細胞在材料上的結構與特性變化。 In treating a damage tissue or organ, to develop a tissue engineering method might be a more optimal approach. In our laboratory, the interaction of material and cells is one of the most important studies of the subject. For otolaryngology, we developed the branching structure of salivary gland, and the morphology and phenotype of acinar cells on biomaterial. |
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Biomedical Polymer
在醫學工程的研究上,選擇生醫材料是一門重要且不易的課題。一個理想的材料需提供良好和適宜的化學物理性質和生物相容性,使細胞擁有較佳的增生能力與展現其功能性。近年來,我們證實幾丁聚醣能有效地提高脂肪幹細胞的幹性相關基因表現和分化能力,且能使大鼠的腎小管上皮細胞平貼生長並生成良好的tight junctions和domes。聚己內酯則是能維持前十字韌帶細胞的特性和促進間葉細胞的軟骨分化能力。因此,我們相信生物高分子於醫學應用上將持續著扮演重要的角色。
How to choose appropriate biomaterials with optimized characteristics for a specific application has become a main medical research focus. An ideal biomaterial should possess appropriate chemical and physical properties to support cell proliferation and function with good biocompatibility. In our laboratory, we have developed many biomaterials to control cell behaviors. For example, adipose-derived stem cells (ASCs) could form three-dimensional spheroids on chitosan to significantly upregulate the pluripotency marker genes. Rat renal proximal tubule cells could form a monolayer on chitosan with well-organized tight junctions, and dome formation. Poly caprolactone (PCL) can improve the phenotype expression of anterior cruciate ligament cells and chondrogenesis of bone marrow mesenchymal cells. Based on these results, we believe that the biopolymers are ideal materials for medical application. |